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Influence of Single Nucleotide Polymorphism of ENPP1 and ADIPOQ on Insulin Resistance and Obesity: A Case-Control Study in a Javanese Population

Single nucleotide polymorphisms (SNPs) in obesity-related genes, such as ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) and adiponectin (ADIPOQ), potentially increase the risk of insulin resistance, the most common metabolic dysregulation related to obesity. We investigated the association of ENPP1 SNP K121Q (rs1044498) with insulin resistance and ADIPOQ SNP + 267G > T (rs1501299) with circulating adiponectin levels in a case–control study involving 55 obese and 55 lean Javanese people residing in Yogyakarta, Indonesia. Allele frequency was determined by a chi squared test or Fisher’s exact test with an expected value less than 0.05. Odds ratios and 95% confidence intervals were estimated by regression logistic analysis. The presence of the Q121 allele of ENPP1 resulted in significantly higher fasting glucose, fasting insulin levels, and HOMA-IR, as compared to homozygous K121 carriers. The risk of insulin resistance was elevated in obese individuals carrying Q121 instead of homozygous K121. Adiponectin level was significantly lower in the obese group as compared to the lean group. Obese individuals carrying homozygous protective alleles (TT) of ADIPOQ tended to have lower adiponectin levels as compared to GT and GG carriers, however, we did not find statistically significant effects of the +276G > T SNP of the ADIPOQ gene on the plasma adiponectin levels or on the development of obesity.

Keywords: ENPP1 gene, ADIPOQ gene, circulating adiponectin, obesity, insulin resistance, metabolic syndrome, SNP K121Q (rs1044498), SNP + 276G > T (rs1501299)

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Informasi Detail
Judul Seri
-
No. Panggil
NONE
Penerbit
UAS : Life.,
Deskripsi Fisik
12 hlm ; Ilus
Bahasa
English
ISBN/ISSN
14220067, 16616596
Klasifikasi
NONE
Tipe Isi
text
Tipe Media
Website
Tipe Pembawa
online resource
Edisi
Vol 11 No 552 Tahun 2021
Subjek
Jurnal Internasional
Influence
Info Detail Spesifik
dapat diakses melalui Website
Pernyataan Tanggungjawab
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